PC1005 - Molecular Basis of Therapeutics 1

Credit points:	03
Year:	2010
Student Contribution Band:	Band 4
Administered by:	School of Pharmacy & Molecular Sciences

Available to students enrolled in the Bachelor of Pharmacy.

The following content (~26 lectures) is common with CH1002. <b>Physical Chemistry.</b> What controls reaction rates? - Reactions, kinetics and mechanism. Electrochemistry - fundamentals and applications in industry and nature. Phase equilibria, colligative properties and chemical partitioning applied to environmental, industrial, physiological and biological process. <b>Organic Chemistry.</b> General features of organic reactions, reactive intermediates, energetics. Mechanisms and applications of major reaction types including relevant biological examples: radical substitution, electrophilic addition, nucleophilic substitution at saturated carbon. nucleophilic addition and substitution at carbonyl goups. Conjugation, resonance and aromaticity. Electrophilic aromatic substitution. Spectroscopy and structure determination. The following content (~12 lectures) is specific to PC1005. <b>Bioinorganic Chemistry.</b> The role of transition metal ions in biological systems: the role of haemoglobin in oxygen transport, vitamins/ mineral supplements (such as cobalt in Vitamin B12). <b>Introductory Medicinal Chemistry.</b> Influence of factors such as size, shape, ionisation state and substituent groups on the biological action of selected drugs.

Learning Outcomes

• develop competence in the application of common laboratory techniques in chemistry, particularly those relevant to the measurement of drug structure and activity;
• in conjunction with Ch1001, to provide the background in key chemical concepts and principles necessary for appropriate understanding of the pharmaceutics, medicinal chemistry and pharmacology subjects in later years of the course.

Graduate Qualities

• The ability to think critically, to analyse and evaluate claims, evidence and arguments;
• The ability to adapt knowledge to new situations;
• The ability to define and to solve problems in at least one discipline area;
• The ability to communicate effectively with a range of audiences;
• The ability to lead, manage and contribute effectively to teams;
• The ability to speak and write logically, clearly and creatively;
• The ability to calculate, produce, interpret and communicate numerical information;
• A coherent and disciplined body of skills, knowledge, values and professional ethics in at least one discipline area;
• The ability to learn independently and in a self-directed manner;
• A commitment to lifelong learning and intellectual development.

Prerequisites:	CH1001
Inadmissible Subject Combinations:	CH1002

Availabilities
Townsville, Internal, Study Period 2
Census Date 26-Aug-2010
Coordinator:	Professor Richard Keene
Lecturers:	Dr Murray Davies, Ms Shiyo Hayashi, Assoc. Professor Michael Oelgemoeller, Dr Gregory Watson, Assoc. Professor Bruce Bowden, Mr Brian Foster, Professor Richard Keene.
Contact hours:	39 hours lectures 12 hours tutorials 30 hours practicals
Assessment:	end of semester exam (70%); laboratory work and reports (30%).

Note: Minor variations might occur due to the continuous Subject quality improvement process, and in case of minor variation(s) in assessment details, the Subject Outline represents the latest official information.